Abstract

DRUG PERMEATION ENHANCEMENT TECHNIQUE BY IONOTOPHORESIS: FOR A TRANSUNGUAL DRUG DELIVERY

Sanjay Kumar Sah*, S. Rajarajan, Benny Baby and Anusha Acharya

ABSTRACT

Transungual tranquilize conveyance framework is connected with the medicine movement through the hard keratinized nail plate to treat the diseases of nail itself in conditions like Onychomycosis and nail psoriasis. Trans ‘ungula medicate process is profoundly attractive in treating nail issue because of its confined impacts, which results in negligible unfavorable fundamental occasions and conceivably improved adherence. The absorption of medications into the nail unit, to the nail plate, is exceptionally alluring to treat nail issue, Nail porousness is anyway very low and points of confinement topical treatment to right on time/mellow ailment states, for example, Onychomycosis (Fungal diseases of the nail). Flow look into on nail pervasion that spotlights on adjusting the nail plate obstruction by methods for compound medications, entrance enhancers just as physical and mechanical strategies. Iontophoresis, most promising novel drug delivery system which have qualitative influenced on the skin permeation and release of drug moiety having poor rate of absorption through skin layers. Usually the electric potential applied for movement of drug is 0.5 mA/cm2. Various nail disorders as well as various approaches for effective transungual drug delivery has been described in this article. This article also provides better understanding of how iontophoresis helps in permeation and factors affecting mechanism of iontophoresis.

Keywords: Transungual drug delivery, Nail disorders, permeation enhancement, Iontophoresis.