Abstract

SOFT GELATIN CAPSULE

Aslam*, Hariom Sharma, Gaurav Kumar Sharma and Kaushal Kishore Chandrul

ABSTRACT

Soft Gelatin Capsules (Soft gel) were developed within the 19th century to mask unpleasant taste and our of drug substances. Since then, many improvements are made with relation to the assembly of those soft capsules. With in the pharmaceutical field, the soft gel dosage forms are increasingly being preferred. Technologically with Soft gel, content uniformity of low-dose drugs has been achieved and also has consumer preference as is straightforward to swallow. Interesting advances have recently been made within the area of developing liquid and semi-solid formulations during a soft gelatin capsule to handle particular bio-performance issues. The Softgel dosage form therefore offers several advantages over other oral dosage forms, like delivering a liquid matrix designed to solubilized rapidly. This improves the oral bioavailability of poorly soluble compounds. Delivery of low and ultra-low doses of a compound using soft gel also ensures decreased plasma variability. However, because of the dynamic nature of the soft gel dosage form, its development and shelf-life stability optimization are fraught with several challenges. This has led to the commercial pharmaceutical and l industries choosing the event of different shell forming materials rather than the traditional capsule shell material gelatin. This review discusses establishment and also the on-going development of the manufacturing technology for liquid fill capsules with specialize in progress and challenges of sentimental gelatin capsules formulation in oral administration for improved solubility and as an absorption-enhancing technique. This considerations form a basis for brand spanking new applications in oral drug delivery Soft gel.

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