Abstract

SYNTHETIC STRATEGIES AND BIOLOGICAL ACITIVITY OF FURAN DERIVATIVE: A REVIEW

Dr. B. Shivkumar, Chavan Gopinath Sahadev*, Sandeepkumar Umarani, Pawar Aravind Revu and Ramesh Gulagi

ABSTRACT

Furan is a 5-membered heterocyclic, oxygen-containing, unsaturated ring compound. The furan nucleus is found in a large number of biologically active materials. The furan ring is a constituent of several important natural products, including furan flavonoids, furan lactones, furanocoumarins, and many natural terpenoids. The synthesis and characterization of a novel family of linear polyurethanes are reported. The original feature stems from the use of furanic monomers, either as diols, or as di isocyanates, or both. Their thermal and photochemical properties were also studied. These moieties are widely employed as antibacterial, antiviral, anti-inflammatory, antifungal, antitumor, antihyperglycemic, analgesic, anticonvulsant, etc. A series of novel di arylhydrazine derivatives containing a furan ring were synthesized by the reaction of 5-fluorophenyl-2-furoyl chloride with substituted benzoyl hydrazide in anhydrous dichloromethane under reflux. These furan derivatives show broad-spectrum antibacterial and insecticidal activities and exhibit pharmacological properties which include serving as anti-depressant3 and anti-inflammatory agents.

Keywords: Furan synthetic strategies, antibacterial, antiviral, anti-inflammatory, antifungal, antitumor, antihyperglycemic, anticonvulsant.