Abstract

A STUDY OF PULSE WAVE VELOCITY AS CARDIAC MARKER FOR CARDIOVASCULAR RISK IN PATIENT WITH POLYCYSTIC OVARIAN SYNDROME USING PERISCOPE

PDSS Prakash*, Rutuja Gawate, Kavya Gowthami, Suresh Singh, and Prerana Jadhav, M. Sudhakar, Praveen Kumar T. and Karuna Sree

ABSTRACT

Background: Polycystic ovarian syndrome (PCOS), or Stein- Leventhal syndrome, is a common endocrine disorder defined by following features, oligoovulation, hyperandrogenism and polycystic ovaries Patients with PCOS have an increased prevalence of metabolic syndrome and traditional atherosclerotic risk factors. Many clinical studies have underlined the connection between PCOS and the cardiovascular risk profile of such female patients, due to a lipid/glucose altered metabolism, hypertension, systemic inflammatory condition. Methodology: A prospective, observational study in 372, 184 in PCOS and 188 in control group, was conducted over a period of 6 months to find out the cardiovascular risk in patients with PCOS. Result: According to our data, the mean age of the women with PCOS was 26 (± 5.7) years, and that of the matched controls was 28.8 (± 5.6) years, (p= 0.274), suggesting that the relatively young PCOS patients may not have increased arterial stiffness. We found a known positive correlation of right brachial-ankle Pulse Wave Velocity with age, BMI and waist hip ratio. In the women with PCOS, PWV showed a relatively positive correlation with BMI and waist hip ratio. Conclusion: In conclusion, the mean PWV was similar between the women with PCOS and the controls, suggesting that relatively young women with PCOS may not have an increased arterial stiffness. However, PWV showed a relatively strong positive correlation with BMI and age only in women with PCOS, suggesting that adiposity and increasing age itself is associated with the decreased arterial stiffness in PCOS patients.

Keywords: Polycystic ovarian syndrome, Cardiovascular, Arterial stiffness, Pulse wave velocity, BMI.