Abstract

A BRIEF ON BENDAMUSTINE HYDROCHLORIDE AND UV-VISIBLE SPECTROPHOTOMETER: A REVIEW

Rohan Chavan*, Shankar M., S. R. Karajagi, Shripad S. Potadar and Basavraj Dashyal

ABSTRACT

Bendamustine hydrochloride (BMH), also known as (4-5-[bis-(2-chloroethyl) amino]-1- methyl-1Hbenzimidazol-2-yl butanoic acid), is a nitrogen mustard. It's used to treat people who have chronic lymphocytic leukemia. It has a mechlorethamine group and a butyric acid substituent on the benzimidazole heterocyclic ring. Bendamustine HCl is a purine-like benzimidazole ring-containing bifunctional mechlorethamine derivative. Electrophilic alkyl teams are established by mechlorethamine and its derivatives. Interstream DNA crosslinks are formed when these groups establish covalent connections with electron-rich nucleophilic moieties. The bifunctional covalent connection can cause cell death by activating the DNA damage stress response and triggering a cascade of events. The main focus of this review is to discuss about the developed analytical methods. All methods are validated according to ICH guidelines and regulatory aspects. The methods are easy, required derivatization and sometime no need of that, directly can be analyze in its pure form, formulation and biological fluids. The products were reported and confirmed structure presented with suitable literature. This review can able to enhance interest for new researcher in the field of pharmaceuticals with respect to drugs.

Keywords: Bendamustine Hydrochloride, UV–Visible Spectrophotometric-1900i.