Abstract

PREPARATION AND CHARACTERIZATION OF REVERSE MICELLAR BASED TOPICAL PRODUCTS OF ERYTHROMYCIN ESTOLATE

Priyanka Rattan*, Twinkle Garg and R. B. Sharma

ABSTRACT

Erythromycin is a well-established molecule, still the challenges of higher poor solubility often result in low bioavailability of orally administered drugs, and thus results in poor therapeutic efficacy. Oral administration of the drug also enhances the pharmacokinetic drug–drug interactions may increase the risk of sudden death from cardiac arrest. To overcome these disadvantages, the study was conducted to prepare reverse micellar based topical products. The prepared formulation was characterized for drug content, organoleptic properties, spreadability, viscosity and drug release kinetics and antimicrobial activity was measured. The particle size, PDI and zeta-potential data ensured the enanmeteric range with substantial stability. The drug loading was quite high and ensured the sufficient amounts of the drug in the specified weight of the gel. The developed formulation showed non-Newtonian nature of rheological behaviour. The drug release studies vouched for the drug delivery potential of the developed system as for 24 hours there was a consistent release of drug from the developed reverse micellar system. The system was found to be quite stable for a period of two months, whereas the lower temperatures were found to be better suited for the stability.

Keywords: Lecithin, Organogels, Reverse micelles, topical route, transdermal, hydrophilic drugs, skin barrier system, Erythromycin estolate.