Abstract

TO DESIGN AND EVALUATE A CHRONOMODULATED DRUG DELIVERY SYSTEM OF A PRO DRUG

Fasi Ahmed Mohd*, Pawan Kumar, R. Sridhar Babu, Amjad Pasha and Mohammed Ahmed

ABSTRACT

Pulsatile system is gaining a lot of interest as it increases patient compliance by means of providing time and site specific drug delivery system. The aim of the present study was to formulate and evaluate pulsatile drug delivery system of Albuterol based on chronopharmaceutical approach for the treatment of asthama. Pulsatile drug delivery systems were prepared by Pulsin Cap technology and the press coat method. The pre-compression parameters of all formulations showed good flow properties and these can be used for tablet manufacture. The post-compression parameters of all formulations were determined and the values were found to be satisfactory. So Finally Based on All Parameters P6 formulation from the pulsin cap technology has been optimized based upon its lag time and the cumulative percentage drug release. the pulsin cap techniques showed the delayed release pattern in a very customized manner. As further into the formulations showed satisfactory result in the DSC study. From DSC graphs it is evident that the polymorphic nature of the drug is intact. Pharmacokinetic study was performed to understand the bioavailibity of the drug and to understand the lag time in the optimized formulations. From the animal studies performed in the rabbits, formulations have shown phenomenal increase in the AUC when compared to that of the Marketed Formulation (Asthalin) i.e 5940.99 ng.mg/ml and 12920.91 ng.mg/ml for marketed formulation and pulsin cap formulation. Both the techniques meet the requisites of the pulsatile drug delivery system, but the pulsin cap technology has a edge with increased bioavailability.

Keywords: Pulsatile drug delivery, Albuterol, Pulsin cap.