Abstract

PREPARATION, OPTIMIZATION AND EVALUATION OF SOLID LIPID NANOPARTICLES FOR BROMOCRIPTINE DELIVERY

Deepika Yadav*, Neelam Poonia, Mamta Yadav, Priyanka Yadav and Lakshita Rao

ABSTRACT

Nanoparticles are a promising drug delivery technology because they can distribute medications in a regulated and targeted manner. They are designed to deliver the medication in close proximity to the target area. Solid lipid nanoparticles (SLNs) are a new type of submicron-sized lipid emulsion in which solid lipid is used instead of liquid lipid (oil). The purpose of this research was to make solid lipid nanoparticles (SLN) containing Bromocriptine Delivery (a proton pump inhibitor) and improve the drug's entrapment efficiency in SLN. The drug was included into by solvent diffusion-solvent evaporation method nanoparticles to achieve this (SLN). The component concentrations were tuned throughout formulation development, and the particles were assessed in terms of particle size, zeta potential, drug loading, percent drug entrapment, stability studies, and drug release behaviour. There was no interaction between the medication and the excipients in FT-IR experiments. The particle size ranged from 58.77nm (FP13) to 114.87nm (FP10) with the selected levels of variables, while the mean was found to be 58.77nm. The % entrapment efficiency varied from 49.98% (FP2) to 84.33 %( FP10) for the levels of variable, while the mean was found to be 66.98%. Stability studies of bromocriptine loaded SLNs were determined at 4±2°C, at 40±2°C/75±5% RH and at for 90 days. In this study, effect of storage on particle size and % entrapment efficiency was studied. The current project also aims to improve the formulation's pharmacological acceptability.

Keywords: Solid lipid nanoparticles, Pantoprazole, Solvent-injection method, Entrapment efficiency.