Abstract

STUDIES ON NOOTROPIC ACTIVITY OF RUTIN AND NARINGIN ON SCOPOLAMINE INDUCED AMNESIA IN RATS USING MORRIS WATER MAZE TASK

Konathala Rajesh*, K.Phani Kumar, S.Kotaiah, Prof. A. Annapurna

ABSTRACT

Nootropics are the new type of compounds affecting learning and memory but are pharmacologically neither CNS stimulant nor depressant. Several nootropics from allopathic system are under clinical trials. In the present study, we have used the Morris water maze to know the effect of Rutin and Naringin on spatial memory. The major advantage of the water maze task over the radial arm maze task is that the rats do not need to be water or food deprived, they are quite motivated to escape from the water. Standard test of learning in which the animal repeatedly searches for a platform hidden beneath the surface of opaque water in round pool. This test is especially sensitive to hippocampal damage and reflects attention, memory and learning strategy. Thus in the present study we have evaluated the nootropic activity of bioflavonoids mainly Naringin and Rutin as they had been reported potential antioxidant activity. Rutin had offered better degree of nootropic activity than Naringin. Both the doses 10mg/kg and 5mg/kg have shown slight different degree of nootropic activity.

Keywords: Nootropic activity, Rutin, Naringin, Scopolamine, Morris water maze task.