Abstract

MEMORY BOOSTING EFFECTS OF CLEOME BRACHYCARPA: ALTERNATIVE APPROACH TO TREAT DEMENTIA?

Sana Sarfaraz*, Rahila Najam, Iqbal Azhar

ABSTRACT

Objective: Herbal preparations have been used since ancient times due to presence of active ingredients which have pharmacological significance and provide therapeutic efficicacy for treatment of various diseases. The aim of study is to evaluate memory boosting and improved muscle coordination activity of Cleome brachycarpa. Materials and Method: Stationary rod test was conducted on mice for 49 days. Ethanolic extract of Cleome brachycarpa was suspended in DMSO and administered orally at dose of 300mg/kg after being adjusted according to weight of mice in grams. Results: The results showed decrease in time taken to cross the rod after sub-chronic dosing and improved grip strength and muscle coordination. Conclusion: From above it is concluded that ethanolic extract of Cleome brachycarpa possesses memory boosting effects and improves muscle coordination, hence this extract can be beneficial for dementia associated with neurodegenerative diseases especially Alzheimers and Parkinsons.

Keywords: Cleome brachycarpa, dementia, bradykinesia, Alzheimer and Parkinsons disease.