Abstract

REVIEW ON HERBAL MEDICINES USED IN PARKINSON’S DISEASE

Dhonde Satish Madhukar*, Ingale Shraddha Kailas, Hase Mayur Vasant, Gorde Pragati Shivaji, Jadhav Meghraj Dnyaneshwar and Ghumare Komal Laxman

ABSTRACT

Parkinson's disease (PD) is the world's most widespread chronic neuron degenerative motion condition affecting more than 10 million people. The characteristic hallmark of PD involves a progressive loss of dopaminergic neuron in the brain's Subetantia Nigra. Considerable beware of this paid recently to the Bio-friendly usage plant-based products for neuron prevention, cure and treatment. Disease is degenerative. The herbal drugs therefore are safer than other drugs. Herbal medicine has its roots in ancient civilizations. It includes the usage of medicinal plants to cure disease and enhance general wellbeing. Although the etiology of Parkinsonism remains unknown, recent studies have suggested that oxidative stress (OS), produces apoptosis which results in mitochondrial defects, neuro inflammation may also play important roles in its pathogenesis. Various agents as 6- Hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine, rotenone a neurotoxin commonly and many more are used in models of PD, induces selective catecholaminergic cell death, mediated by reactive oxygen species (ROS) and mitochondrial defect towards the herbal treatment for parkinsonism.

Keywords: Parkinson Disease, Herbal Drug Treatment, Ayurveda, Neuroprotective, Antioxidant, Antiapoptotic.