Abstract

ASSESSMENT OF TRANSFORMING GROWTH FACTOR-BETA (TGF- ?) AND ALBUMIN TO CREATININE RATIO (ACR) IN PATIENTS WITH TYPE 2 DIABETIC NEPHROPATHY

Hussein Saeed Abbas*, Shaymaa Zahraw Nada and Alaa Abbas Fadhel

ABSTRACT

Background: Diabetes mellitus is the leading cause of end stage renal disease worldwide. Diabetic nephropathy (DN) is one of the most common microvascular consequences of diabetes. Early identification of DN, on the other hand, is vital for better clinical treatment, and therapeutic intervention at an early stage of the disease is vital to avoid progression to ESRD and dialysis. Objective:- The aim of this study is to investigate the diagnostic utility of transforming growth factor-beta(TGF-β) as a biomarker for early detection of nephropathy in type 2 diabetes mellitus patients. Patient and Methods: The current study was designed as case control study, involved 120 individuals, 60 patients with type 2 diabetes mellitus (T2DM) group and 60 participants who are apparently healthy was used as control group. The patients group were subdivided into three equal groups according to their urinary albumin to creatinine ratio (ACR): 20 normoalbuminuric patients, 20 microalbuminuric patients, 20 macroalbuminuric patients. Results: Serum TGF-beta levels (Mean ±SD) in theT2DM with Normoalbuminuria, T2DM with Microalbuminuria, T2DM with Macroalbuminuria and control groups were (128.6±32.9), (331.4±101.0), (364.1±98.1), (109.1±14.8) respectively with highly significant difference P(

Keywords: Diabetic nephropathy, Type 2 diabetes mellitus, transforming growth factor-beta.