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FORMULATION AND EVALUATION OF INDOMETHACIN PARACETAMOL FAST DISSOLVING TABLET
Sourabh Dilip Khaladkar*, Bhagyshri Satish Rupanwar, Gopal K. Munde and Prof. Vikas B. Kandekar
ABSTRACT Fast dissolving tablet Indomethacin with Paracetamol has been shown anti-inflammatory analgesic activity COX- 2 inhibitor. Convenient mode of administration, there is need to develop fast disintegrating dosage form, particularly one that disintegrates and dissolve when contact with saliva and can be administered without water. Indomethacin paracetamol were prepared by direct compression method by using superdisintegrant crosspovidone, sodium starch glycolate, mannitol, gum karaya, banana powder to enhance patient compliance prepared batches of tablet were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time, drug release, stability. Analytical technique used like FTIR, DSC and dissolution study. In vitro dissolution study carried out disintegration approach phosphate buffer PH 6.8 dissolution medium of F4 batch comparison gum karaya and banana powder shows better drug release. Post compression parameter like hardness 3.2kg/cm2, friability 0.41 IPF4 showed improved drug dissolution 98.49% in 30 min and In-vitro dispersion 67 seconds. The F4 was the best among all formulation of fast dissolving tablet. The FTIR and DSC showed no interaction between the drug excipients. Optimized batch IPF4 showed good drug release. Keywords: Crosspovidone, Sodium starch glycolate, Mannitol, Banana powder, Gum karaya. [Download Article] [Download Certifiate] |