Abstract

STUDY OF PATTERN OF ANTIBIOTIC SUSCEPTIBILITY FROM CENTRAL VENOUS CATHETERS IN ICU PATIENTS

Suharshi Gupta*

ABSTRACT

Background: Intensive care units (ICU) are one of the most prevalent places for hospital-acquired infections. Medical aggressive devices like Central Venous Catheters (CVC) endanger mucosal and skinny barrier, are mainly responsible. The study was aimed at investigating the prevalence and antimicrobial susceptibility pattern of the isolated microorganisms from the CVC in ICU patients. Method: A cross-sectional-prospective analytical study was carried out on 300 patients, aged 18 years and above, in the Department of Microbiology, Govt. Medical College, Jammu (J&K), India, over a period of 3 months, i.e. from December 2020 to February 2021, among patients admitted in ICU Department. Results: 162 (54.0%) males and 138 (46.0%) females, with CVCs were investigated. The average age of these patients was 46.92 ± 19.38 years. Catheter in jugular vein 143 (47.67%) was main cause CVCs in patients. Average hospitalization in case of positive samples was significantly high at 41.5 ± 27.5 days, (p=0.032). Acinetobacter baumannii (18.2%) was the main MDR isolate, followed by E-Coli (8.7%), Fungi (8.3%), Enterobacter (6%). Sensitivity percentage was high for Imipenem (79.3%), Amikacin (62.0%) and Morepenem (62.0%), however resistance was high for drugs like: Ampicillin, piperacillin, etc. Klebsiella isolates were sensitive to amikacin and meropenem. Conclusion: All E. coli isolates were resistant to imipenem and piperacillin and no single antibiotic could show sensitivity to majority of microorganisms. Therefore, critical care practitioners should be proficient in the techniques of central venous catheterization to avoid the unnecessary load of infections arising out of them.

Keywords: Central Venous Catheters, Hospital Acquired Infection, Antimicrobial Susceptibility, Isolates.