Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MICROSPHERES OF KETOPROFEN USING DIFFERENT POLYMERS

Sania Hasan, Neeraj Sharma, Naveen Gupta, Ankita Shukla and
Dharmendra Singh Rajput*

ABSTRACT

Microspheres have been explored extensively for their use in the field of drug delivery and various polymers have been utilized for the formulation of the microspheres, which in turn have been assessed for different purposes. Microspheres are one of the multiple unit dosage forms. Eventually the total dose and few adverse reactions may be reduced since a steady plasma concentration is maintained. Microspheres are potential drug delivery carrier systems in the segment of novel drug delivery and are prepared using assorted polymers. Ketoprofen is a non-steroidal anti-inflammatory drug. The chemical name for Ketoprofen is 2-(3-benzoylphenyl)-propionic acid. It has a pKa of 5.94 in methanol: water (3:1) and an n-octanol: water partition coefficient of 0.97 (buffer pH 7.4). Ketoprofen is a white or off-white, odourless, nonhygroscopic, fine to granular powder, melting at about 95°C. It is freely soluble in ethanol, chloroform, acetone, and ether and soluble in benzene and strong alkali, but practically insoluble in water at 20°C. Ketoprofen is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums. The present study was aimed to prepare and evaluated chitosan containing ketoprofen microspheres prepared by ionotropic gelation method for pulsatile release of drug at the part of GIT and decrease distinct tissue protection in the stomach. This method offers to prepare microspheres which are important in controlling the release rate and the absorption of aceclofenac from the intestinal region. Variation in polymer concentration was studied systemically for their influence on the encapsulation efficacy, particle size and in vitro drug release.

Keywords: Ketoprofen, Aceclofenac, Microspheres.