Abstract

COMPARATIVE STUDY OF ANTI INFLAMMATORY AND ANTHELMINTIC ACTIVITIES OF T. ORIENTALIS BY IN-VITRO METHOD

Akshata N.*, Kaustav Mahapatra, Kiran Bilgundi, Kiran Choudhary, Kalaiyarasu M. and Junaid Mushtaq Peer

ABSTRACT

Trema orientalis is an evergreen shrub/tree which can grow upto 18m in height, and up to 1.5 m tall in the savannah.. It has a basally swollen bole, heavy branching and has round spread like a crown. Large traces of tannins, saponins, flavonoids (simiarenol, simiarenone, trematol) are present in the leaves of T.orientalis. The above notified phytoconstituent shows various pharmacological effects in different test models. These activities include- laxative, hypoglycemic, antipyretic, analgesic, anti-microbial properties, anticonvulsant activity, and antiplasmodial property. Inflammation is a defensive response when the cells of the body are damaged by microbes, physical agents or chemical agents, which is a form of stress and is characterised by redness, pain, heat, and swelling and loss of function in the injured area, in an attempt to heal itself. Helminths are regarded as one of the most common agents that cause infection in humans. Some of the examples of diseases caused by helminths are onchocerciasis and filariasis caused by the filarial worms. Comparative study of anthelmintics and anti inflammatory study has been done on trema Orientalis. Method: Invitro screening by inhibition of albumin denaturation, Heat induced haemolysis, Hypotonicity induced haemolysis, Assessment of Anthelmintic activity(24) methods were uses to evaluate the comparative study of anthelmintic and anti inflammatory effect of plant extract of T. orientalis. Results: In the present study the results confirm the potential anti-inflammatory and anthelmintic activity in the extract of trema orientalis. Also, in the comparative study, it indicates that the extract of Trema orientalis possesses anthelmintic activity to a greater extent than that of anti-inflammatory.

Keywords: Anthelmintics, anti-inflammatory, Trema Orientalis, Inflammation, Hemolysis.