Abstract

LERCANDIPINE: USED IN TREATMENT OF HYPERTENSION

Mayuri Babasaheb Gaikwad*, Prachi P. Udapurkar and Lahu. D. Hingane

ABSTRACT

We all know that lercanidipine is theurapeutically used for hypertension and also it is calcium channel blocking agent. This is highly permable & also very poorly soluble drug. So there are lot of techniques form poorly soluble drug. Enhancement of for the determination of this lercandipine drug herby simply precise accurate as well as sensitive UV spectrometric method was developed. Lercanidipine is a lipophilic, dihydropyridine calcium antagonist with a long receptor half-life. Its slow onset of action helps to avoid reflex tachycardia associated with other dihydropyridines (DHPs). It produces even and sustained blood pressure lowering with once-daily dosing. It has equivalent antihypertensive efficacy to many other agents and is effective as initial monotherapy or in combination. Efficacy has been demonstrated in elderly as well as younger patients and also in the presence of other risk factors. Lercanidipine is well tolerated with DHP-associated adverse effects occurring early in treatment. The incidence of pedal edema and subsequent withdrawals has been found to be lower with lercanidipine than with amlodipine or nifedipine gastrointestinal transport system. Preclinical and preliminary clinical findings suggest lercanidipine may have beneficial effects on atherosclerosis and left ventricular hypertrophy. The efficacy and tolerability profiles of lercanidipine make it a suitable choice for treating hypertension in a wide range of affected patients.

Keywords: UV Spectrometry, validation, lercandipine, monotherapy, tolerability, nefedipine, amlodipine.