Abstract

PROTECTIVE EFFECT OF AQUEOUS LEAF EXTRACTS OF AEGLE MARMELOS AND CAMELLIA SINENSIS IN OIL INDUCED DYSLIPIDEMIC RATS

Priyanga Suriyamoorthy, Margret Rosaland Fathima Mary, HemmalakshmiSubrhamanian, Devaki Kanagasapabathy*

ABSTRACT

The present study appraised the protective activity of aqueous leaf extracts of Aegle marmelos and Camellia sinensis and its possible mechanism of action. Male Witar albino rats were randomly assigned to five groups: Groups I normal control; Group II hyperlipidemic with coconut oil and ground nut oil (8 ml/ rat/ day); Group III Hyperlipidemic treated with Aegle marmelos extract (250 mg / kg b. wt./ day) and Group IV Hyperlipidemic treated with Camellia sinensis extract (250 mg / kg b. wt./ day) orally. The whole study lasted for 28 days. The results clearly demonstrate the positive effects of Aegle marmelos and Camellia sinensis in oil administration. The amount of free and ester cholesterol were significantly reduced in the treatment group. Amount of TBARS was elevated in the induction group as an effect of high radical generation. This is a classical marker for the cell damage, as an increase of TBARS, the cell damage in the induction group is possible which was further evidenced by the elevated SGOT and ALP levels in induction group. Amount of SOD and CAT were decreased in the induction group. Upon treatment with the plant extracts there is significant raise in SOD and CAT levels and simultaneous decrease in the levels of TBARS, SGOT and ALP. The probable mechanism of action of the plants is assumed to be by their anti-oxidant property.

Keywords: Aegle marmelos, Camellia sinensis, TBARS, SOD, CAT.