Abstract

REPORT ON AN OVERVIEW OF NEPHROTOXICITY AND DISORDERS OF KIDNEY

Sarveshwar Jaiswal, Surabhi Dwivedi* and Poonam Kumari

ABSTRACT

Estimation of nephrotoxicity through blood tests comprise the measurements of blood urea nitrogen (BUN), the concentration of serum creatinine, glomerular filtration rate and creatinine clearance. In this review, the study aimed to recognize biomarkers that are more sensitive than the traditional markers and that are more expressive of pre-renal damage. Nephrotoxicity assays such as measurement of the concentration of serum creatinine or BUN do not have the sensitivity and selectivity need to determine nephrotoxicity in an early phase. Acute kidney injury is a regular diagnosis, present in up to 60% of severe patients, and its third main source is drug toxicity. Nephrotoxicity can be explained as any renal injury give rise to directly or indirectly by medications, with acute renal failure, tubulopathies, and glomerulopathies as usual clinical presentations. Early detection is necessary for the good progress of the patient, with a depletion of renal exposure to the poisonous agent, which requires knowing the risk factors and biomarkers.

Keywords: tubulopathies, and glomerulopathies.