Abstract

COMPARISON OF THE AMINO ACID STRUCTURES OF INSULIN AND GLUCAGON USING QUANTUM CHEMISTRY

*Manuel González Pérez, Carmen María Juárez-Rivero, Lizeth Hernández-Ramírez. Danyah Paola Sánchez-Priego, José Ricardo López-Palestina.

ABSTRACT

The investigations of glucose and glucagon metabolism increase every day in the scientific community. In this research, we compare the structures of glucagon and insulin from their elemental composition of amino-acids (AAs). Hamiltonian technic: It used the Hamiltonian combinatorial possibilities to perform all the valence electron’s hops between each substance. It used HC Semi-Empirical Parameterized Model number 3 (SE-PM3) to draw the corresponding molecules. We found that glucagon has more AAs in its structure due to its catabolic function with glycogen. The arms of both glucagon and insulin are the Histidine (His) and, arginine (Arg). Insulin uses these arms to carry glucose and release it at its GLUT receptors. Glucagon uses these arms to break down glycogen. The other AAs serve other functions, such as displacement. In general glucagon has more grip than insulin due to its role in catabolizing glycogen. In contrast, insulin has fewer claws due to its glucose monomer transport function.

Keywords: Amino acid, Insulin, Glucagon, Quantum chemistry, Hyperchem.