Abstract

MANAGEMENT OF WOMEN WITH RECURRENT MISCARRIAGE WITH ASPIRIN PLUS HEPARIN VERSUS ASPIRIN AND ORAL PREDNISOLONE

Dr. Alaa Issa Hamzah*

ABSTRACT

Prior to the 20th week of gestation, RPL is defined as at least two or three consecutive abortions. Only one to five percent of all pregnancies are affected with RPL. As a result of this study, we will be able to determine if low dose aspirin and steroids are more effective than LMWH with regard to treating women who suffer from recurrent miscarriages. Repetitive miscarriage clinics in the Obstetrics and Gynecology Department of Iraqi Hospital were used to perform this randomized clinical research on 150 pregnant women who met the inclusion criteria and provided informed permission. Aspirin (75 mg twice daily) and prednisone (5 mg twice daily) were provided to 75 pregnant women in Group 1. (20mg). Aspirin and heparin tablets of 75 pregnant women were given to them in the second group. From the time of the pregnancy's onset through the time of birth, ultrasounds were performed on both groups every two weeks. Group I had a live birth rate of 32.2 percent higher than group II, and group I had 74% and group II had 42% live birth rates, OR (C.I. 95 percent 4.128 [2.142-7.952] RR (C.I. 95 percent 1.75 [1.401-2.505]p0.001 with a significant difference between the two groups.. The development of bruising differed significantly between the two groups (P0.05). The combination of prednisone and low-dose aspirin may be a useful treatment for women who suffer from idiopathic pregnancy loss.

Keywords: Aspirin, Steroids, Unexplained Recurrent Miscarriage, heparin LMWH.