Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF RIVAROXABAN IMMEDIATE RELEASE TABLET BY DIRECT COMPRESSION METHOD

Shruti V. Raundal*, Avish D. Maru, Mitesh P. Sonawane, Mayur M. Sonawane, Sudarshan B. Borse and Vaishnavi S. Sake

ABSTRACT

The goal of this study is to develop and evaluate Rivaroxaban immediate release tablets. Rivaroxaban is a BCS class II medication, is a blood thinner medicine that is administered orally. Preparation of Tablets were use direct compression technique. There are nine distinct formulas available (F1-F9) were created utilising several super disintegrating chemicals. Various Superdisintegrants and excipient concentrations were used by all batches, the concentrations of SSG and PVPK-30 were changed. The concentrations of PVP K-30 and SSG were measured during the dissolution of Rivaroxaban. IR tablets in 900 ml phosphate buffer pH 6.8 at 50 rpm. The dissolution profile of Rivaroxaban IR tablets having varying concentrations of SSG and PVP K-30 varies. In comparison to other formulas, the F3 batch produces the best outcomes.

Keywords: Immediate release tablets, Anticoagulant, Direct compression, Superdisintegrants.