Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING FILM OF APIXABAN BY SOLVENT CASTING METHOD

Mayur M. Sonawane*, Avish D. Maru, Mitesh P. Sonawane, Shruti V. Raundal, Sudarshan B. Borse and Vaishnavi S. Sake

ABSTRACT

The demand for innovative dose forms has increased in order to improve patient compliance. In recent years, mouth dissolving dosage forms have gained appeal because they do not require water for administration. Apixaban is a blood thinner that is commonly used to prevent heart attacks. Because it is a water soluble medication, its absorption and pharmacological effect are largely dependent on its solubility. The goal of this study was to create, test, and refine a mouth-dissolving film containing Apixaban. Two distinct film-forming agents, HPMC-E5 and propylene glycol, were used to create the films. In the polymer solution, apixaban was distributed. The oral dissolving time and other film parameters were determined to be satisfied using the solvent casting method. When the film is wetted by saliva, it quickly hydrates, clings to the tongue, and disintegrates and dissolves to release the medication for oral mucosal absorption or gastrointestinal absorption when eaten. Film endurance was adequate for the created films. The film took 30 seconds to dissolve and 1 minute to release the medication, respectively. The study concludes that a mouth dissolving film could be a promising new medicine dosage form for water-soluble pharmaceuticals.

Keywords: Mouth dissolving dosage, Apixaban, Anticoagulant, Oral mucosal absorption.