Abstract

PHYTOCHEMICAL SCREENING AND IN-VITRO ANTHELMINTIC ACTIVITY OF COLOCASIA ESCULANTA LEAVES

Praveen Kumar Dasari* and Bondili Sadhana

ABSTRACT

Now a days parasitic (helimnths) infections are growing rapidly worldwide and numerous synthetic Antihelmintic drugs are in use for the treatment of helminthiasis but they posses some allergic manifestations as well as adverse effects in order to overcome that effects natural Anthihelmintic agents are required in present scenario. Thus this present research work deals with phytochemical screening and invitro antihemlmintic activity of Colocasia Esculanta leaves for that purpose Indian earthworms, Pheretima posthuma having anatomical and physiological resemblance with intestinal helimnths. The Adult worms are cleaned in normal saline solution before they were placed in to 10ml of respective formulation. To observe anthelmintic activity, all the investigations were carried out by Methanolic, Aqueous and Acetone extract with different concentrations of 10, 20, 50mg/ml, significant activity like time of paralysis and time of death were noted. At highest concentrations of 50mg/ml of methanolic extract, a significant anthelmintic activity was observed and compared with piperazine citrate (10, 20, 50mg/ml as standard reference and distilled water as control. Herbal extract showed similar antihelmintic activity compared to that of standard drug at highest concentration 50mg/ml

Keywords: Colocasia esculanta leaves, Phytochemical screening, Pheretima posthuma, Piperazine citrate.