Abstract

ANTI ANXIETY AND ANTI DEPRESSANTS ACTIVITY OF HIBISCUS ROSA IN RATS

Manoj Verma*, Satkar Prasad and Shailesh Kumar Ghatuary

ABSTRACT

Anxiety is a cardinal symptom of many psychiatric disorders and an almost inevitable component of many medical and surgical conditions. It is found that administration of 400 mg/kg Hibiscus rosa sinensis or 20 mg/kg DZP for 7 days significantly reduced the immobility time in FST. These results provide support for the potential anti anxiety and antidepressant activity of Hibiscus rosa sinensis and contribute towards validation of the traditional use of Hibiscus rosa sinensis in the treatment of emotional disorders. In this study, elevated plus maze test were used to evaluate the anti anxiety and anti depressant activity of extract Hibiscus rosa sinensis of in albino mice. The elevated plus maze is considered to be an etiologically valid animal model of anxiety. In the elevated plus maze, the open arms are more fear provoking than the closed arms. The reduction in entry and time spent in open arms are the indications of the high level of fear or anxiety. The results obtained in this study suggest that the extract of the leaves of Hibiscus rosa sinensis possesses anti anxiety and anti depressant activity. Thus, Hibiscus rosa sinensis has potential clinical application in the management of anxiety disorders.

Keywords: Hibiscus rosa sinensis, anti anxiety, Anti depressant, Albino mice, Elevated plus maze.