Abstract

HEPATOPROTECTIVE ACTIVITY OF ALOE VERA EXTRACT IN RODENT MODEL

Akanksha Verma*, Satkar Prasad and Shailesh Kumar Ghatuary

ABSTRACT

Determination of protective effect of Aloevera leaf extract against paracetamol induced Hepatotoxicity, firstly level of GSH and SOD was checked. GSH and SOD level was tested in vehicle treated group after that Paracetamol treated group and then 200mg/kg of plant extract along with Paracetamol treated group and after that 400mg/kkg of plant extract along with Paracetamol treated group. In-vivo antioxidant activity was measured through a set of enzymes including SGOT, SGPT, and ALP. The levels were measured and it indicated that the extract had significant antioxidant activity however the results obtained were dose dependent the higher the dose (400 mg/kg) the better activity. The extract administered at dose 400 mg/kg showed better activity.

Keywords: Aloevera, Hepatotoxicity, Paracetamol, Hepatoprotective.