Abstract

REVIEW ON: TRANSDERMAL PATCHES AS TRANSDERMAL DRUG DELIVERY SYSTEM

Prashant Surnar*, Nilesh Bhosale, Dhanashri Zope, Payal Babar and Shubham Mohite

ABSTRACT

Transdermal drug delivery has made a significant contribution to medical practise, but it has yet to realise its full potential as a replacement for oral drug administration and hypodermic injections. The clinical usage of first-generation transdermal delivery systems for the delivery of tiny, lipophilic, low-dose medicines has increased steadily. Clinical solutions have also been developed employing second-generation delivery techniques such as chemical enhancers, non-cavitational ultrasound, and iontophoresis; the ability of iontophoresis to alter distribution rates in real time adds functionality. Microneedles, thermal ablation, microdermabrasion, electroporation, and cavitational ultrasound are all used in third-generation delivery methods to target the stratum corneum's barrier layer. A transdermal patch is a medicated adhesive patch that is applied to the skin to deliver a particular amount of medication into the bloodstream through the skin. It aids in the recovery of an injured bodily part. The patch provides a controlled release of medication into the patient, usually through a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive, which is an advantage of transdermal drug delivery over other types of delivery systems such as oral, topical, I.V., I.M., and so on. The fundamental disadvantage of transdermal delivery systems is that the skin acts as a very efficient barrier; as a result, only drugs with tiny molecules may easily permeate the skin and be supplied this way. This review article covers the basics of transdermal patches, such as the different types, how they're made, and what factors influence them, among other things.

Keywords: Transdermal drug delivery system, Transdermal patches, Transepidermal absorption, proliposomes, TRX, EVAC, IPM.