Abstract

DEVELOPMENT AND EVALUATION OF GEMCITABINE LOADED CARBOXYMETHYL CELLULOSE/GRAPHENE QUANTUM DOTS NANOCOMPOSITE HYDROGEL FILMS AS AN ANTICANCER DRUG DELIVERY SYSTEMS

Keerthana C. K.*

ABSTRACT

The present work to develop and evaluate of gemcitabine loaded carboxymethyl cellulose/graphene quantum dot nanocomposite hydrogel films as a potential anticancer drug delivery system. Creating anticancer properties in the hydrogel film could make it as a candidate for treating cancer tissues. In this work, a novel hydrogel nanocomposite films with anticancer properties were designed via incorporation of graphene quantum dot (GQD) as a nanoparticle into carboxymethyl cellulose (CMC) hydrogel and using gemcitabine (GEM) as drug model with broad-spectrum anticancer properties. Drug release studies was carried out in two different pH and the MTT assay was evaluated for GEM-loaded CMC/GQD nanocomposite hydrogel films against blood cancer cells. The prepared nanocomposite hydrogel films were characterized using Fourier transform infrared (FT-IR), UV–Vis spectroscopy, scanning electron microscopy (SEM), permeability and mechanical properties. The prepared CMC/GQD nanocomposite hydrogel films showed an improvement in vitro swelling, degradation, water vapor permeability and pH-sensitive drug delivery properties along with not significant toxicity against blood cancer cells. According to the obtained results, this nanocomposite hydrogel films can be proposed to use as an anticancer film and drug delivery system.

Keywords: Gemcitabine, Quantum Dots, Nanocomposite hydrogel films, Anticancer drug Delivery.