Abstract

FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE SUSTAINED-RELEASE ORAL MATRIX TABLETS

R. Vijay*, Dhayalan M., Harsimran Kaur Kohli and Tejashwini H.

ABSTRACT

The present investigation was carried out to develop the sustained delivery of metformin hydrochloride for an effective and safe therapy using three polymers, Such as 1). Chitosan, 2). Hydroxypropyl methylcellulose (HPMC) and 3). Xanthan gum. The term modified-release dosage forms is used to describe products that alter the timing and rate of release of drug substance. A modified-release dosage form is defined as one for which the drug release characteristics of time course and location are chosen to accomplish therapeutic or convenience objectives not offered by conventional dosage forms such as solutions, ointments, normally kidney function. Formulations of chitosan MS1 drug release are 87%, xanthum gum MS4 was 90%, and finally MS7 with hydroxypropyl methylcellulose was 93% which exhibited the highest drug release retardation, also had the lowest matrix concentration. Hence, a lower concentration of polymer such as hydroxypropyl methylcellulose is optimized batch suitable to prepare metformin hydrochloride tablets compared to higher concentrations.

Keywords: Chitosan, Hydroxypropyl methylcellulose (HPMC) and Xanthan gum.