Abstract

SODIUM VALPROATE INDUCED HEPATIC JAUNDICE IN PEDIATRIC PATIENT – A RARE CASE REPORT

Ashwini Doddannavar*, Laxmi Pattanashetti and Sughosh Mutalik

ABSTRACT

Purpose: Valproate sodium is one of the most often used medications for the treatment of childhood epilepsy because of the low prevalence of hepatotoxicity and the widely held belief that regular monitoring of liver function potentially detect early signals of reversible toxicity. It is the most common neurological illnesses, affecting approximately 50 million people globally, with children accounting for two-thirds of those affected. Because of its unpredictability, epilepsy is regarded to be quite disabling. Method: A patient was admitted with history of viral mengioencephalitis on treatment of Sodium valproate medication however; showed the clinical symptoms of hepatic jaundice. Result & Conclusion: She was treated with discontinuing the causative drug as soon as possible and combining supportive therapy with either immunoglobulin or corticosteroid.

Keywords: Hepatitis, Hepatic jaundice, Sodium valproate, epilepsy, meningoencephalitis.