Abstract

AN INVESTIGATION ON ANTI-UROLITHIATIC ACTIVITY OF TYPHA ELEPHANTINA IN EXPERIMENTAL RATS

Karunakar Hegde*, Vidyashree B. and Prathiksha

ABSTRACT

The Typha elephantina was evaluated for its antiurolithiatic activity in experimentally induced urolithiatic rats. Urolithiasis was induced by administration of sodium oxalate (70mg/kg) intraperitonially to adult male Wistar albino rats (150-200g) for seven days served as a prophylactic regimen and ethylene glycol (0.75%v/v) in drinking water for 28 days served as a curative regimen. Two doses of methanolic extract of Typha elephantina 200mg/kg and 400mg/kg were subjected for the evaluation of antiurolithiatic activity. Cystone (750mg/kg) was served as standard in both the model. It was observed that experimentally induced urolithiasis in both the conventional model was found to have elevated calcium, oxalate, uric acid concentration in urine and also serum creatinine and uric acid were elevated. Similarly, reduction in magnesium level was observed. Treatment with extract 200mg/kg and 400mg/kg significantly restored all elevated urine and serum biochemical parameters in both prophylactic and curative regimen. Kidney homogenate analysis and assessment of physical parameters confirmed the anti-urolithiatic effects of the extract. Histopathological findings also showed improvement in kidney architecture in extract treated group. The present study concluded that Typha elephantina was found to be effective against urolithiasis.

Keywords: Antiurolithiasis, Ethylene glycol, Sodium oxalate, Typha elephantina.