Abstract

EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF ARTOCARPUS HETEROPHYLLUS SEEDS IN MICE

Karunakar Hegde*, Mayble Mary Lyngkhoi and Jayalaxmi Gowda

ABSTRACT

The objective of the proposed study is to investigate the Antidepressant effects of Ethanol extract of Artocarpus heterophyllus seeds (EEAHS) in mice. Mice were divided into 4 groups and each group consisting of n=6 animals. Group 1 received vehicle, Group 2 received imipramine (10mg/kg p.o.) and Group 3 and Group 4 treated with lower (200mg/kg, p.o.) and higher (400mg/kg, p.o.) doses of Artocarpus heterophyllus respectively for 14 days. This effect was comparable to that of the imipramine (10mg/kg p.o.). Effects of different treatments were subjected for the evaluation of immobility time and biochemical estimation. Both the lower and higher dose of EEAHS showed dose dependent significant decrease in the immobility time in the tail suspension and force swim model, in comparison with control animals. The result obtained was comparable with that of the control group and standard drug imipramine. The outcome of the present study provides the evidence that the ethanolic extract of Artocarpus heterophyllus seeds reported to contained flavonoids and it helps to reduce depression. In conclusion the present data indicate that the administration of EEAHS to mice shown antidepressant activity by reducing the immobility time.

Keywords: Anti-depressants, Artocarpus heterophyllus, Depression, Force swim test, Jackfruit, Tail suspension.