Abstract

FORMULATION AND EVALUATION OF COMPRESSED TABLETS OF ACECLOFENAC LOADED MICROSPONGE FOR SUSTAINED DRUG DELIVERY

Srilatha Malvey* Gudikandula Harika, Therala Shalini and Naresh Kshirasagar

ABSTRACT

The new investigation behind the present work was to develop microsponges compressed tablet based novel drug delivery system for sustained action of Aceclofenac microsponges through Quai-emulsion solvent diffusion method was engaged using Ethyl cellulose (EC), and Poly vinyl Pyrrolidone (PVP) as carrier with drug-polymer ratio for preparation of microsponges. For optimization purposes, several factors are considered in investigation. Characterization techniques followed for the formed microsponges were Fourier Transformer Infrared (FTIR), Scanning Electron Microscopy (SEM), particle size analysis, drug loading in vitro drug release studies were carried out. It was found that there is no interaction between the drug-excipients was confirmed by FTIR results. The drug polymer ration showed great impact on encapsulation efficiency, particle size and drug content. Binocular microscopic studies and SEM studies showed that morphological microsponges are spherical and porous in nature and with mean particle size of 10 μm. The microsponges were compressed into tablets followed by in vitro drug release studies by using paddle type method, in vitro drug release results depicted that microsponges with ethyl cellulose 1:1.5 drug-polymer and 0.5 g of PVA were more effective to give extended drug release 80.14±0.261 % at the end of 12 hrs, which is possible to show sustained action of drug.

Keywords: Microsponges compressed tablets, Aceclofenac, Sustained action.