![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
DEVELOPMENT AND VALIDATION OF NEW ANALYTICAL METHOD FOR THE SIMULTANEOUS ESTIMATION OF AZELNIDIPINE AND TELMISARTAN IN PHARMACEUTICAL DOSAGE FORM
M. Guruvareddy* and Usman
ABSTRACT For the simultaneous measurement of Azelnidipine and Telmisartan in Tablet dosage form, a simple, accurate, and exact approach was established. Agilent C18 150 x 4.6 mm, 5m chromatography was used. contains a mobile phase 0.1 percent orthophosphoric acid buffer: Acetonitrile was pushed through the column at a flow rate of 1.0ml/min in a 55:45 ratio. This approach made use of 0.1 percent orthophosphoric acid buffer. The temperature was kept at 30°C. The optimal wavelength chosen was 240 nm. The retention times of Azelnidipine and Telmisartan were found to be 2.149 minutes and 2.684 minutes, respectively. The percent RSD of Azelnidipine and Telmisartan were found to be 0.3 and 0.2, respectively. percentage Azelnidipine and Telmisartan recovered at rates of 99.85 and 99.83 percent, respectively. The LOD and LOQ values derived from Azelnidipine and Telmisartan regression models were 0.02, 0.06 and 0.17, 0.57, respectively. Azelnidipine's regression equation is y = 10903x + 290.61, while Telmisartan's is y = 21706x + 1725.6. Because retention durations and run times were reduced, the technique created was easy and cost-effective, and it may be used in frequent quality control tests in industries. Keywords: Azelnidipine, Telmisartan, RP-HPLC. [Download Article] [Download Certifiate] |