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UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF DASATINIB IN BULK AND TABLET DOSAGE FORM
Somnath Patil, Nilesh Desale* and Somasharan Kale
ABSTRACT The aim of present work is to develop a simple, accurate, precise, rapid, economical UV Spectrophotometric method for the estimation of Dasatinib in bulk and tablet dosage form. Method: Spiked Dasatinib arrangement was checked over UV- visible extend for its absorbance maxima. Results: The absorbance maximum was determined at 232 nm using 0.1% formic acid as a solvent. The relationship coefficient over the concentration extend of 40-60 μg/ml was found 0.9995. The LOD and LOQ of Dasatinib were found 0.687445 and 2.083166 respectively. The method was successfully applied to Dasatinib in marketed formulation and results were in good agreement with label claims. Conclusion: Depending on the results, the given method can be successfully applied for the assay of Dasatinib in various tablet dosage form. Keywords: Dasatinib, 0.1% Formic Acid, Absorbance Maxima, UV –Visible Spectrophotometer, Method development & validation. [Download Article] [Download Certifiate] |