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UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF ONDANSETRON HYDROCHLORIDE IN BULK AND FORMULATION
Dr. Yogesh Thorat*, Dr. Avinash Hosmani, Onkar Wale, Nitin Mane, Prachet Bagewadikar
ABSTRACT UV Spectrophotometric Method Development and Validation for quantitative estimation of Ondansetron Hydrochloride (OND). UV Spectrophotometric method has been widely employed in the determination of individual components in a mixture of fixed-dose combinations. We aim to develop a spectroscopic method for estimation of the Ondansetron HCL in ternary mixture by using UV spectrophotometry. The method was validated as per ICH guidelines. The drug obeyed Beer’s law and showed a good correlation. It showed absorption maxima at 309 nm in simulated saliva. The recovery studies confirmed the accuracy and precision of the method. It was successfully applied for the analysis of the drug in bulk and could be effectively used for routine analysis. Keywords: UV spectrophotometry, Ondansetron hydrochloride, Simulated saliva, Tablets. [Download Article] [Download Certifiate] |