ANTHELMINTIC SCREENING OF CRUDE EXTRACTS OF PISOLITHUS ARRHIZUS
R. Meghalatha*, Ashok Chittaragi, S. Nataraja and M. Krishnappa
ABSTRACT
The World Health Organization estimates that a staggering two billion
people harbor parasitic worm infections. Parasitic worms also infect
livestock and crops, affecting food production with a resultant
economic impact. Despite this prevalence of parasitic infections, the
research on antihelmentic drug is poor. As per WHO, only few drugs
are frequently used in the treatment of helminthes in human beings.
Antihelmentic from the natural sources may play a key role in the
treatment of these parasitic infections.In the present investigation,
anthelmintic screening of crude extracts of Pisolithusarrhizus. The
phytochemical analysis revealed that the major bioactive components
of the mushrooms are terpenoides, polyphenols, saponins, tannins and glycosides.In view of
this chloroform, ethyl acetate and methanol extracts of fruiting bodies of P. arrhizuswere
evaluated separately for the activity on adult Indian earthworms, Pheretimaposthuma, using
Piperazine citrate as reference standards.Three concentrations (20, 40 and 60mg/ml) of each
extracts were studied in activity, which involved the determination of time of paralysis and
time of death of the worm. The results indicated that the methanolic extract was more potent
than the chloroform and ethyl acetate solvent extract. All extracts showed effective
anthelmintic activity at 60 mg/mlconcentration.
Keywords: Pisolithusarrhizus, Solvents, Helminthes, Anthelmintic activity,Piperazine citrate.
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