Abstract

A REVIEW: A REVIEW OF FORMULATION AND EVALUATION OF SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM OF MODEL DRUG

Devanand Dadarao Pawar* and Dr. R. B. Wakade

ABSTRACT

Diclofenac, non-steroidal anti-inflammatory drug (NSAID) belongs to BCS Class II drug with low dissolution and poor aqueous solubility. The main aim of the present study was to improve the solubility and dissolution rate of diclofenac using self-emulsifying drug delivery technique. Micro emulsion region was formed by preparing the ternary phase diagram. Ratio, 0.5:0.5 and 0.3:0.7 was selected as the self- emulsification region for the development of formulation. Drug – excipient studies were performed by FT-IR. Parameters were evaluated include time of emulsification, freezing and thawing and dissolution. The present research work describes SEDDS of Diclofenac using olive oil, Tween 20 and PEG200 prepared by simple vortex in the mixture at 40 °c and packed in hard gelatine capsule shell of 00 size. In vitro dissolution was carried out using USPII by 6.8 pH buffer at 75 RPM and samples were measured at 276 nm using UV-Visible spectroscopy. Keywords: Diclofenac, SEDDS, Tween 20, PEG 200 and Olive oil.

Keywords: Poor water soluble, Patient Compliance, Anti-inflammatory, Analgrsic.