Abstract

A REVIEW OF RESVERATROL CONTAINING LIPOSOMAL GEL FOR SKIN CANCER THERAPY

Deepika Yadav*

ABSTRACT

Resveratrol (RSV), a natural plant extract, has been shown to promote cell death and cell cycle arrest in a variety of cancer cell types in vitro. Resveratrol is a polyphenolic phytoalexin found in grapes, berry skins, and Japanese knotweed roots that is thought to be a powerful antioxidant, anti-inflammatory, neuroprotective, and cardioprotective agent. RSV anticancer effects are mediated through a variety of cell signalling pathways, including cell cycle arrest, tumour cell proliferation suppression, induction of apoptosis and differentiation, angiogenesis, and invasion, adhesion, and metastasis inhibition. RSV has been proven to have a wide range of biological benefits in recent years, including anti-inflammatory and neuroprotective characteristics, as well as protection against oxidative stress and cancer. Resveratrol is well-known for its anti-inflammatory and anti-photoaging properties in the treatment of proliferative skin disorders. Researchers have previously established RSV's capacity to alleviate oxidative stress and mitochondrial dysfunction in Parkinson's disease mice. Low water solubility, as well as poor UV, pH, and temperature-dependent stability, are all challenges in the development of topical liposomal gel of Resveratrol drug delivery systems and dosage forms. However, because of its low oral bioavailability and short biological half-life, its favourable therapeutic effects are limited; thus, topical administration is a viable option for treating a variety of dermatological conditions. The goal of this Review paper is to explore method of preparation of Liposomes and advantages over other approaches, Resveratrol's mode of action, therapeutic efficacy, and physicochemical features, as well as contemporary technological attempts to improve its stability.

Keywords: Resveratrol (RSV), Liposomal gel, Skin cancer, Anti-cancer effects, Skin disorders.