Abstract

IN SITU GELLING SYSTEM: NANOPARTICLE BASED STRATEGIES FOR BRAIN TARGETING

Kalyani Pranav Kayande*, Snehal Sadashiv Kudale, Supriya Sangram Nikam, Suraj Tanaji Gavale and Ritwik Virendra Shinde

ABSTRACT

In situ gelling system that bypass the BBB, delivers the medications to the desired site of action, control the release kinetics, and reduce peripheral toxicity. The in situ gel idea reduces disorders caused by limited bioavailability. Several pre-clinical reports found that intranasal medication delivery to the brain utilizing in situ gels has a lot of promise. While producing those gels, safety concerns about nasal mucosa toxicity, medication delivery to target brain regions, and the computation of the required dose must all be taken into account. The olfactory area into nerve fibers and the vascular pathway are the key methods for medication delivery from the nose to the brain. Intranasal drug delivery using drug-loaded lipid nanocarriers has a number of advantages, including the ability to cross biological barriers (BBB, first-pass metabolism, and intestinal degradation of the drug), high patient compliance (in comparison to injection), rapid drug absorption, and improved bioavailability (especially for lipophilic drugs). The goal of this review is to concentrate on in situ-based gels that are used to administer drugs through the intranasal route. Drug administration via the nose to the brain is being regarded as a possible technique for bypassing the BBB and delivering diverse therapeutic medicines with low cerebral bioavailability

Keywords: In situ gel, mechanisms, lipid nanoparticles, intranasal delivery, polymers.