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ECO-FRIENDLY PREPARATION AND BIOLOGICAL ASSESMENT OF Cr(III), Mn(II) AND Fe(III) COMPLEXES WITH PHENYLACETYLUREA AND BUTANOATE ION LIGANDS
Arunachalam, A.*, Ramachandramoorthy,T., Padmavathy, S., Narendran, R. andAmala Fathima Rani,S.
ABSTRACT Phenylacetylurea (PAU) is a biologically active, bidendate neutral ligand. The present study deals with the microwave assisted preparation, physico-chemical, spectral and biological characterization of Cr(III), Mn(II) and Fe(III) complexes containing PAU and butanoate ion (but) ligands. The molecular formulae of the complexes were arrived at from the estimation of metals, electrical conductivities, and effective magnetic moment (μeff) values. The electronic spectral data indicate the probable geometry of the complexes. The antibacterial and anti fungal screening of the above three complexes against the bacteria, viz., Raoultella planticola, Vibrio cholerae, Lactobacillus brevis, Pseudomonas aeruginosa and Micrococus luteus and fungi, viz., Candida albicans, Aspergillus oryzae, Aspergillus niger, Aspergillus flavus and Aspergillus sojae were carried out. The results indicate that the Fe(III) complex exhibits higher antibacterial activity than Cr(III) and Mn(II) complexes and pure ligands. All the three complexes show low anti fungal activity than the reference compound, ketokonazole. The diphenylpicrylhydrazyl (DPPH) free radical scavenging activity of the above three complexes are lower than the standard compound, vitamin-C. Keywords: Cr(III), Mn(II) and Fe(III) complexes, Phenylacetylurea, Antibacterial, Anti fungal. [Download Article] [Download Certifiate] |