Abstract

EVALUATION OF PATTERN OF ADVERSE DRUG REACTIONS (ADR) IN A TERTIARY CARE HOSPITAL IN MADURANTHAGAM TALUKA TAMIL NADU- SOUTH INDIA

*Dr. Vishwasrao Sunil Mhatarba, Dr. Sufala Sunil Vishwasrao and Farheen Syed Fazaludeen

ABSTRACT

Introduction & Background: Advancement in the research and development has resulted in the manufacturing of highly effective drugs to improve the quality of human life with increase in life expectancy. This positive outcome has always not been proved to be efficient because unnoticed or unreported adverse drug reaction (ADR) may impact on human life causing increased mortality & morbidity. Severe Adverse drug reactions can be highly fatal. However, medical practitioner’s vigilance while administering these drugs may prevent casualties. Although data on ADR is published but is lacking with specific information about the severity & outcome. Hence, we planned to evaluate the patterns of ADR and to assess severity and causality of ADR with specified scale. Materials & Methods: A descriptive study was conducted from December to May 2019 after obtaining approval from IEC. All hospitalized patients of Karpaga Vinayaga Hospital who developed ADR were included in study while patients with poisoning, drug overdose, drug abuse & blood and blood components were excluded. Observations & Results: In age group of 21–41years, 49.01% had ADRs. Skin (70.6%) was most commonly involved organ while 29.41 % were severe reactions. After causality assessment, ADRs were classified as possible (13.7%), probable (56.8%), and doubtful (29.41%). Major reporting bulk was by doctors 45 (88.3%) followed by nurse 4 (7.8%). Conclusion: Incidence of cutaneous reactions was higher as compared to other systems. Though nurses spend more time in care of the patient, incidence of their reporting is very less as compared with that of doctors. Therefore, they require sensitisation on pharmacovigilance and ADR reporting.

Keywords: Adverse drug reaction, Pharmacovigilance.