Abstract

THE SIGNIFICANCE OF BIOCHEMICAL PARAMETERS RELATED TO BONE DISEASE

Charavi R.* and Kusu Susan Cyriac

ABSTRACT

Bone diseases are the disorders, caused by abnormalities of minerals such as calcium, phosphorous, magnesium, sodium and potassium. These disorders can be differentiated from the larger group of genetic bone disorders where there is a defect in a specific cell type that leads to bone disorders. The deficiency of phosphate will cause osteomalacia due to insufficient formation of hypoxypatite associated with low intake of calcium. Magnesium may affect the intestinal uptake. Low potassium to sodium intake ratios are more strongly related to cardiovascular diseases. For example, genetic or hereditary hypophosphatemia may cause the metabolic bone disorder osteomalacia. Although there is no current treatment for the genetic condition, replacement of phosphate often corrects or improves the metabolic bone disorders. Very high levels of ALP can be caused by liver problems. Hypothyroidism has received lesser attention as it effects on bone mineral metabolism is minimal.

Keywords: Bone disease, Biochemical parameters.