Abstract

MEMORY ENHANCING ACTIVITY OF GINGER: A REVIEW

Poonam Dogra*, Shreya Chauhan, Palvi, Diksha, Palvi Thakur and Manav Dogra

ABSTRACT

Age-related illnesses are becoming increasingly common as people live longer lives. There is an increasing need for medicinal remedies to dementia cases around the world, however the currently available medications do not match those needs. Natural chemicals, employed in ancient medicine because of their positive benefits and great tolerance, have recently caught the scientific community's attention. A look at the anti-and Alzheimer's anti-vascular dementia effects of ginger (Zingiber officinale), two of the most frequent and debilitating dementias, is presented in this review. Ginger chemicals have been shown to have therapeutic benefits on Alzheimer's Disease and Vascular Dementia models, as well as some human studies. All of this research suggests that ginger's components may play a role in both treating and preventing the condition. Alzheimer's disease (AD) is a neurodegenerative illness that primarily affects the elderly and is associated with a variety of dysfunctions, the most notable of which is a decline in cognitive function. This disease is brought on by various cellular abnormalities, such as amyloid-beta accumulation and hyperphosphorylation of tau protein as well as neurotransmitter imbalance, apoptosis, and oxidative stress as well as inflammatory reactions. It is desirable to find new treatments for Alzheimer's disease that have the ability to treat other afflictions, such as side effects and pharmacokinetic issues. Many diseases can be fought with the help of phytochemicals, whose widespread use in humans prompted scientists to investigate their effectiveness. For memory deficits, Zingiber officinale, Gingeroids, Shogaoids, and Bornols were tested. After screening for eligibility, clinical trials are included in vitro. Oxidative stress and apoptosis are the most commonly discussed interventive mechanisms. The pathophysiology of Alzheimer's disease and signaling pathways are linked in a new study. In vivo investigations and clinical trials help to clarify the results and scores of cognition measures. In the current review, several traditional characteristics of ginger consumption in AD are also discussed. Further research is needed to assess the pharmacological and medicinal features of ginger and its components in order to improve and alleviate memory dysfunctions.

Keywords: Zingiber officinale, Alzheimer’s disease, Degenerative disease, Dementia, Neuroprotective.