Abstract

PREPARATION OF CLOTRIMAZOLE-SILVER NANOPARTICALS: TOPICAL ANTIMYCOTIC NANOGEL DELIVERY

Ritu Verma, Ramnivas*, Anish Kumar and Shailendra Tiwari

ABSTRACT

Nanotechnology has unbolted individual platform to explore in a hybrid therapeutic region. At present, nanometal technology is in the embattled field which has some extraordinary advantages of exceptionally very small metal nanoparticle particle sizes. In this research we focused on the antimycotic properties of silver nanoparticles with the combination of niosomes and nanogel which shows the synergistic effects with clotrimazole antifungal drug. This topical preparation can used for the treatment against various pathogens. We synthesized silver nanoparticles using Carbopol concentration 0.04, 0.05, 0.06, 0.07, 0.08g/ml which shows orange to brown color after some time it converts into greyish color. UV visible spectra of silver nanoparticles at different concentration were analyzed and drug loading and entrapment efficiency was performed which was found to be fairly good.

Keywords: Clotrimazole UV spectroscopy, nanoparticle, fungal, nanogel.