Abstract

DEVELOPMENT AND EVALUATION OF SILVER NANOPARTICLES OF LULICONAZOLE FOR ANTIFUNGAL ACTIVITY

Ajay Kumar*, Dr. Abhishek Soni, Ashish Kumar and Jyoti Devi

ABSTRACT

A nanoparticle is a very small particle of a substance with a diameter of 1 to 100 nanometres (nm). Silver nanoparticles have a variety of physical and chemical properties, including high thermal and electrical conductivity, surface-enhanced Raman scattering, chemical stability, catalytic activity, and nonlinear optical behaviour. Luliconazole is a novel imidazole antifungal with a broad spectrum of activity that prevents ergosterol synthesis by inhibiting sterol 14a-demethylase. The FITR spectra of the new formulation were determined to demonstrate surface characterizations and ensure the relationship between AgNPs and luliconazole. Vander wall or hydrogen bonding between the silver nanoparticle's citrate ion and the luliconazole's imidazole group causes the contact. NaBH4 and trisodium citrate were used in the reaction mixture to make luliconazole-loaded silver nanoparticles, with NaBH4 acting as a reducing agent and sodium citrate primarily acting as a capping material to prevent particle aggregation and further growth. The percentage of drug entrapment in all generated formulations ranged from28.69±0.88 to86.25±0.32. The proportion of drug entrapment increased linearly with the concentration of silver nitrate, indicating that as the concentration of silver nitrate increased, so did the percentage of drug entrapment. Luliconazole drug entrapment was determined to be 80.48±0.31 percent in the improved formulation LSN14.

Keywords: silver nanoparticles (AgNPs), luliconazole, carbopol, NaBH4, trisodium citrate.