Abstract

COMPARATIVE EVALUATION OF DIFFERENT MARKETED BRANDS OF ITRACONAZOLE

Nehanshu Patel, Thorat Dinesh, Rathod Pravin, Raju Yadav, Sagar Gayakwad, Chaudhari Ajay, Mohammad Talha Vahora*, Rikin Patel, Vedish Patel, Dr. Richa Dayaramani and Dr. Rahil G. Bhura

ABSTRACT

Efficacy of pharmaceutical dosage form generally depends on their formulation and manufacturing methods, hence it is likely that the quality of dosage form may vary. The free azole nitrogen competes for oxygen at the catalytic heme of cytochrome P-450 enzyme. Inhibition of cytochrome P-450 enzyme prevents the synthesis of ergosterol in fungal cell membranes by limiting the C14 demethylation of lanosterol, which is critical for the synthesis of ergosterol. The study was exclusively experimental that used IP and other standard books to check in vitro quality of Itraconazole tablet using different analytical techniques and procedure. Test for weight variation, hardness, friability, disintegration time and dissolution were conducted. The dissolution test was performed at pH 6.8 for both brands of the tablet. Further all the tablet passed weight variation, hardness, and friability and disintegration test as per the pharmacopoeial standard. Hence we can conclude that both the brands of tablets are equal quantity of active pharmaceutical ingredient (API). Both the brands having higher and lower costs exert similar action.

Keywords: Itraconazole, In vitro, Dissolution test.