Abstract

SEDDS: CHALLENGING APPROACH TOWARDS THE BIOAVAILABILITY

Akash Samanta* 

ABSTRACT

Oral drug distribution systems with tablets and capsules are the maximum conservative and commonly used dosage forms due to their comparative safety, constancy in storage and ease of making in bulk. They also have healthier patient acquiescence and allow self-administration associated with parenteral dosage forms. Still, recently oral delivery of 50% of the drug complexes is hampered for the high lipophilicity of the drug. Their formulation has developed gradually tough as the mainstream of these drugs has poor aqueous solubility. In current years up to 40 - 45% of new chemical objects revealed by the pharmaceutical industry are poorly soluble or lipophilic compounds, low aqueous solubility which source of poor oral bioavailability, high intra- and intrasubject changeability, and lack of dose balance. In the oral preparation of such complexes, several efforts - such as reducing particle size, the custom of wetting agents, co-precipitation, and preparation of solid dispersions have been completed to adjust the dissolution profile and thereby recover the absorption rate. Freshly, more attention is intensive on lipid-based inventions to advance the bioavailability of poorly water-soluble drugs. A figure of procedures is used to overcome this problem with micronization, solid dispersions, liposomes etc. Self-Emulsifying Drug Delivery System is one such technique, which is used to boost the dissolution and bioavailability of lipophilic drugs but which have poor aqueous solubility.

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