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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

COCRYSTALLIZATION OF KETOPROFEN AND BENZOIC ACID BY USING SOLVENT- DROP GRINDING METHOD

Jayashree Gaja*, K. Jesindha Beyatricks and S. Tharani

ABSTRACT

The purpose of this work was to prepare ketoprofen-benzoic acid cocrystal by solvent drop grinding method to improve solubility of the drug Ketoprofen. Ketoprofen and conformer benzoic acid in molar ratio 1:1 was used to formulate molecular complex using methanol as solvent. Characterization of cocrystal was done by Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) Spectroscopy. The formed cocrystal of Ketoprofen exhibits different physicochemical characteristics compared to the constituent materials. The prepared cocrystal showed an improvement in solubility with respect to the pure drug.

Keywords: Co-crystals, Co-formers, Solvent drop technique, Ketoprofen, Solubility.

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