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DEVELOPMENT AND EVALUATION OF ORAGANOGEL OF ECONAZOLE
Jaya Sharma*, Dr. Dilip Agrawal, Mohit Khandelwal, Ashok Kumar Sharma
ABSTRACT
The main purpose of this research was to develop a effective and safe topical formulation (Organogel) of Econazole to reduce the dose concentration of the active drug, to improve patient compliance, to promote less side effects and increase local fast absorption and onset action. Econazole is an optically active imidazole derivative antifungal agent. It has been found to have broad-spectrum of antifungal activity against pathogenic fungi. Methods: Topical Organogel formulations of Econazole were prepared using tween-80 with different penetration enhancer with their different concentrations. Nine different formulations of Econazole were prepared and evaluated with respect to their colour, Spreadability, viscosity parameter, determination of pH, drug content, in vitro drug release studies, antifungal studies, and stability studies. Results: FT-IR and DSC study revealed that there were no any significant interaction between the drug, excipients and polymers. All the prepared formulations of Econazole show acceptable standard physical properties. The drug content and percentage yield were higher for F5 formulation among all formulation F5 shows better drug release. Stability study of the best formulation F5 (Coconut oil) shows that there was no difference in drug content and in vitro drug release studies. Conclusion: From the above observation results that this F5 formulation (Carbopol and Coconut oil) may be more encouraging topical substitute for the healing of fungal infections in the skin. Keywords: Econazole, Organogel, Skin, Fungal, Stability study. [Download Article] [Download Certifiate] |